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BMCBI
2006
239views more  BMCBI 2006»
13 years 4 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
BMCBI
2005
178views more  BMCBI 2005»
13 years 4 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...
ACMSE
2006
ACM
13 years 10 months ago
Reconstructing networks using co-temporal functions
Reconstructing networks from time series data is a difficult inverse problem. We apply two methods to this problem using co-temporal functions. Co-temporal functions capture mathe...
Edward E. Allen, Anthony Pecorella, Jacquelyn S. F...
BMCBI
2007
215views more  BMCBI 2007»
13 years 4 months ago
Learning causal networks from systems biology time course data: an effective model selection procedure for the vector autoregres
Background: Causal networks based on the vector autoregressive (VAR) process are a promising statistical tool for modeling regulatory interactions in a cell. However, learning the...
Rainer Opgen-Rhein, Korbinian Strimmer
KDD
2002
ACM
171views Data Mining» more  KDD 2002»
14 years 5 months ago
Mining complex models from arbitrarily large databases in constant time
In this paper we propose a scaling-up method that is applicable to essentially any induction algorithm based on discrete search. The result of applying the method to an algorithm ...
Geoff Hulten, Pedro Domingos