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RECOMB
2006
Springer
14 years 5 months ago
Inferring Positional Homologs with Common Intervals of Sequences
Inferring orthologous and paralogous genes is an important problem in whole genomes comparisons, both for functional or evolutionary studies. In this paper, we introduce a new appr...
Guillaume Blin, Annie Chateau, Cedric Chauve, Yann...
BMCBI
2006
143views more  BMCBI 2006»
13 years 4 months ago
Fast estimation of the difference between two PAM/JTT evolutionary distances in triplets of homologous sequences
Background: The estimation of the difference between two evolutionary distances within a triplet of homologs is a common operation that is used for example to determine which of t...
Christophe Dessimoz, Manuel Gil, Adrian Schneider,...
BMCBI
2010
101views more  BMCBI 2010»
13 years 4 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
WABI
2007
Springer
102views Bioinformatics» more  WABI 2007»
13 years 11 months ago
Homology Search with Fragmented Nucleic Acid Sequence Patterns
The comprehensive annotation of non-coding RNAs in newly sequenced genomes is still a largely unsolved problem because many functional RNAs exhibit not only poorly conserved sequen...
Axel Mosig, Julian J.-L. Chen, Peter F. Stadler
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
13 years 11 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...