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» Machine learning methods for metabolic pathway prediction
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BMCBI
2010
115views more  BMCBI 2010»
13 years 4 months ago
Machine learning methods for metabolic pathway prediction
Background: A key challenge in systems biology is the reconstruction of an organism's metabolic network from its genome sequence. One strategy for addressing this problem is ...
Joseph M. Dale, Liviu Popescu, Peter D. Karp
CIBCB
2005
IEEE
13 years 6 months ago
Pathway Analyst--Automated Metabolic Pathway Prediction
—Metabolic pathways are crucial to our understanding of biology. The speed at which new organisms are being sequenced is outstripping our ability to experimentally determine thei...
Luca Pireddu, Brett Poulin, Duane Szafron, Paul Lu...
CMSB
2004
Springer
13 years 10 months ago
Modelling Metabolic Pathways Using Stochastic Logic Programs-Based Ensemble Methods
In this paper we present a methodology to estimate rates of enzymatic reactions in metabolic pathways. Our methodology is based on applying stochastic logic learning in ensemble le...
Huma Lodhi, Stephen Muggleton
WABI
2009
Springer
155views Bioinformatics» more  WABI 2009»
13 years 11 months ago
A Markov Classification Model for Metabolic Pathways
Background: This paper considers the problem of identifying pathways through metabolic networks that relate to a specific biological response. Our proposed model, HME3M, first ide...
Timothy Hancock, Hiroshi Mamitsuka
IJBRA
2006
59views more  IJBRA 2006»
13 years 4 months ago
Predicting altered pathways using extendable scaffolds
: Many diseases, especially solid tumors, involve the disruption or deregulation of cellular processes. Most current work using gene expression and other high-throughput data, simp...
B. M. Broom, T. J. McDonnell, D. Subramanian