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» Minimal cut sets in biochemical reaction networks
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BIRD
2008
Springer
158views Bioinformatics» more  BIRD 2008»
13 years 7 months ago
A Computational Method for Reconstructing Gapless Metabolic Networks
Abstract. We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of b...
Esa Pitkänen, Ari Rantanen, Juho Rousu, Esko ...
BMCBI
2008
152views more  BMCBI 2008»
13 years 5 months ago
Predicting biological system objectives de novo from internal state measurements
Background: Optimization theory has been applied to complex biological systems to interrogate network properties and develop and refine metabolic engineering strategies. For examp...
Erwin P. Gianchandani, Matthew A. Oberhardt, Antho...
BMCBI
2010
149views more  BMCBI 2010»
13 years 5 months ago
RuleMonkey: software for stochastic simulation of rule-based models
Background: The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be...
Joshua Colvin, Michael I. Monine, Ryan N. Gutenkun...
BMCBI
2008
119views more  BMCBI 2008»
13 years 5 months ago
On deducing causality in metabolic networks
Background: Metabolic networks present a complex interconnected structure, whose understanding is in general a non-trivial task. Several formal approaches have been developed to s...
Chiara Bodei, Andrea Bracciali, Davide Chiarugi
JCB
2008
96views more  JCB 2008»
13 years 5 months ago
Computing Knock-Out Strategies in Metabolic Networks
Given a metabolic network in terms of its metabolites and reactions, our goal is to efficiently compute the minimal knock out sets of reactions required to block a given behaviour....
Utz-Uwe Haus, Steffen Klamt, Tamon Stephen