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BMCBI
2010
105views more  BMCBI 2010»
13 years 5 months ago
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement
Background: The Medium-chain Dehydrogenases/Reductases (MDR) form a protein superfamily whose size and complexity defeats traditional means of subclassification; it currently has ...
Joel Hedlund, Hans Jörnvall, Bengt Persson
BMCBI
2010
123views more  BMCBI 2010»
13 years 24 days ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
RECOMB
2007
Springer
14 years 6 months ago
A Feature-Based Approach to Modeling Protein-DNA Interactions
Transcription factor (TF) binding to its DNA target site is a fundamental regulatory interaction. The most common model used to represent TF binding specificities is a position spe...
Eilon Sharon, Eran Segal
BMCBI
2008
130views more  BMCBI 2008»
13 years 5 months ago
Structural descriptor database: a new tool for sequence-based functional site prediction
Background: The Structural Descriptor Database (SDDB) is a web-based tool that predicts the function of proteins and functional site positions based on the structural properties o...
Juliana S. Bernardes, Jorge H. Fernandez, Ana Tere...
NAR
2007
132views more  NAR 2007»
13 years 5 months ago
Expanded protein information at SGD: new pages and proteome browser
The recent explosion in protein data generated from both directed small-scale studies and largescale proteomics efforts has greatly expanded the quantity of available protein info...
Robert S. Nash, Shuai Weng, Benjamin C. Hitz, Rama...