23 search results - page 3 / 5 » Non-additivity in protein-DNA binding |
BMCBI
2007
13 years 6 months ago
2007
Background: Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are of this type,...
RECOMB
2003
Springer
14 years 6 months ago
2003
Springer
The availability of whole genome sequences and high-throughput genomic assays opens the door for in silico analysis of transcription regulation. This includes methods for discover...
CIBCB
2007
IEEE
14 years 10 days ago
2007
IEEE
Abstract— This paper presents a parametric model to estimate the DNA-protein binding time using the DNA and protein structures and details of the binding site. To understand the ...
BMCBI
2005
13 years 5 months ago
2005
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
BMCBI
2006
13 years 6 months ago
2006
Background: Tangle analysis has been applied successfully to study proteins which bind two segments of DNA and can knot and link circular DNA. We show how tangle analysis can be e...