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» Optimal design of thermally stable proteins
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BIOINFORMATICS
2008
119views more  BIOINFORMATICS 2008»
13 years 4 months ago
Optimal design of thermally stable proteins
Motivation: For many biotechnological purposes, it is desirable to redesign proteins to be more structurally and functionally stable at higher temperatures. For example, chemical ...
Ryan M. Bannen, Vanitha Suresh, George N. Phillips...
ASPDAC
2008
ACM
130views Hardware» more  ASPDAC 2008»
13 years 6 months ago
Architecture-level thermal behavioral characterization for multi-core microprocessors
In this paper, we investigate a new architecture-level thermal characterization problem from behavioral modeling perspective to address the emerging thermal related analysis and o...
Duo Li, Sheldon X.-D. Tan, Murli Tirumala
BMCBI
2010
101views more  BMCBI 2010»
13 years 4 months ago
Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots
Background: Knottins are small, diverse and stable proteins with important drug design potential. They can be classified in 30 families which cover a wide range of sequences (1621...
Jérôme Gracy, Laurent Chiche
GECCO
2005
Springer
119views Optimization» more  GECCO 2005»
13 years 10 months ago
A multi-objective evolutionary approach to peptide structure redesign and stabilization
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...
Tim Hohm, Daniel Hoffmann
ASPDAC
2008
ACM
196views Hardware» more  ASPDAC 2008»
13 years 6 months ago
A CAD tool for RF MEMS devices
A stable, multiple energy domain and multi scale simulation tool for Microsystems is developed. A structured design methodology is adopted for design and optimization of RF MEMS sh...
Rajesh Pande, Rajendra Patrikar