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BMCBI
2008
108views more  BMCBI 2008»
13 years 5 months ago
Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
Background: High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications...
David A. Nix, Samir J. Courdy, Kenneth M. Boucher
FCCM
2011
IEEE
311views VLSI» more  FCCM 2011»
12 years 9 months ago
String Matching in Hardware Using the FM-Index
—String matching is a ubiquitous problem that arises in a wide range of applications in computing, e.g., packet routing, intrusion detection, web querying, and genome analysis. D...
Edward Fernandez, Walid Najjar, Stefano Lonardi
BMCBI
2006
135views more  BMCBI 2006»
13 years 5 months ago
TF Target Mapper: A BLAST search tool for the identification of Transcription Factor target genes
Background: In the current era of high throughput genomics a major challenge is the genome-wide identification of target genes for specific transcription factors. Chromatin immuno...
Sebastiaan Horsman, Michael J. Moorhouse, Victor C...
BMCBI
2011
12 years 9 months ago
Faster Smith-Waterman database searches with inter-sequence SIMD parallelisation
Background: The Smith-Waterman algorithm for local sequence alignment is more sensitive than heuristic methods for database searching, but also more time-consuming. The fastest ap...
Torbjørn Rognes
FPL
2008
Springer
150views Hardware» more  FPL 2008»
13 years 7 months ago
Compiler generated systolic arrays for wavefront algorithm acceleration on FPGAs
Wavefront algorithms, such as the Smith-Waterman algorithm, are commonly used in bioinformatics for exact local and global sequence alignment. These algorithms are highly computat...
Betul Buyukkurt, Walid A. Najjar