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» PatternHunter: faster and more sensitive homology search
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BIOINFORMATICS
2002
64views more  BIOINFORMATICS 2002»
13 years 5 months ago
PatternHunter: faster and more sensitive homology search
Bin Ma, John Tromp, Ming Li
BIBE
2004
IEEE
13 years 9 months ago
Efficient Methods for Generating Optimal Single and Multiple Spaced Seeds
Biologists highly rely on good algorithms for finding homologous regions in bimolecular sequences. An advanced homology search program named PatternHunter has recently been develo...
I-Hsuan Yang, Sheng-Ho Wang, Yang-Ho Chen, Pao-Hsi...
NAR
2007
152views more  NAR 2007»
13 years 4 months ago
COMPASS server for remote homology inference
COMPASS is a method for homology detection and local alignment construction based on the comparison of multiple sequence alignments (MSAs). The method derives numerical profiles f...
Ruslan Sadreyev, Ming Tang, Bong-Hyun Kim, Nick V....
BIBE
2005
IEEE
126views Bioinformatics» more  BIBE 2005»
13 years 11 months ago
Suboptimal Alignments Improve the Detection of Weak Homologs in Sequence Database Searches
PSI-BLAST remains one of the popular tools for searching remote homologs in sequence databases. We recently demonstrated that hybrid alignment can function as the alignment core f...
Yuheng Li, Mario Lauria, Ralf Bundschuh
BMCBI
2010
101views more  BMCBI 2010»
13 years 5 months ago
Hidden Markov model speed heuristic and iterative HMM search procedure
Background: Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require con...
L. Steven Johnson, Sean R. Eddy, Elon Portugaly