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BIOCOMP
2006
13 years 6 months ago
Petri Net Based Model Of The T Cell Receptor Signaling Pathway
Intracellular signaling pathways as well as the interactions and coordination that exist among them are complex and difficult to visualize and understand. Computer-based models of...
Srinidhi Jayasuryan, Anil Bamezai, Vijay Gehlot
BMCBI
2006
205views more  BMCBI 2006»
13 years 5 months ago
Application of Petri net based analysis techniques to signal transduction pathways
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Andrea Sackmann, Monika Heiner, Ina Koch
RECOMB
2006
Springer
14 years 5 months ago
De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
CMSB
2007
Springer
13 years 11 months ago
A Unifying Framework for Modelling and Analysing Biochemical Pathways Using Petri Nets
We give a description of a Petri net-based framework for modelling and analysing biochemical pathways, which unifies the qualitative, stochastic and continuous paradigms. Each per...
David Gilbert, Monika Heiner, Sebastian Lehrack
BMCBI
2010
110views more  BMCBI 2010»
13 years 5 months ago
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
Background: Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and th...
Haruna Imamura, Nozomu Yachie, Rintaro Saito, Yasu...