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RECOMB
2004
Springer
14 years 4 months ago
Predicting Genetic Regulatory Response Using Classification: Yeast Stress Response
We present a novel classification-based algorithm called GeneClass for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple orga...
Manuel Middendorf, Anshul Kundaje, Chris Wiggins, ...
HISB
2011
99views more  HISB 2011»
12 years 4 months ago
Quantitative Modeling the Saccharomyces cerevisiae FLR1 Regulatory Network Using an S-System Formalism
—We address the problem of finding a mathematical model for the genetic network regulating the stress response of the yeast Saccharomyces cerevisiae to the fungicide mancozeb. A...
Dulce Calçada, Susana Vinga, Ana T. Freitas...
BMCBI
2007
138views more  BMCBI 2007»
13 years 4 months ago
A systematic approach to detecting transcription factors in response to environmental stresses
Background: Eukaryotic cells have developed mechanisms to respond to external environmental or physiological changes (stresses). In order to increase the activities of stress-prot...
Li-Hsieh Lin, Hsiao-Ching Lee, Wen-Hsiung Li, Bor-...
BMCBI
2006
108views more  BMCBI 2006»
13 years 4 months ago
Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress
Background: In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses t...
Huiquan Wang, Craig J. Benham
BMCBI
2006
137views more  BMCBI 2006»
13 years 4 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...