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BIOINFORMATICS
2010
123views more  BIOINFORMATICS 2010»
13 years 5 months ago
Prediction of protease substrates using sequence and structure features
David T. Barkan, Daniel R. Hostetter, Sami Mahrus,...
CSB
2004
IEEE
115views Bioinformatics» more  CSB 2004»
13 years 8 months ago
PoPS: A Computational Tool for Modeling and Predicting Protease Specificity
Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremel...
Sarah E. Boyd, Maria J. García de la Banda,...
BMCBI
2006
85views more  BMCBI 2006»
13 years 5 months ago
SVM-based prediction of caspase substrate cleavage sites
Background: Caspases belong to a class of cysteine proteases which function as critical effectors in apoptosis and inflammation by cleaving substrates immediately after unique sit...
Lawrence J. K. Wee, Tin Wee Tan, Shoba Ranganathan
BMCBI
2010
141views more  BMCBI 2010»
13 years 5 months ago
Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles
Background: Enzymes belonging to acyl:CoA synthetase (ACS) superfamily activate wide variety of substrates and play major role in increasing the structural and functional diversit...
Pankaj Khurana, Rajesh S. Gokhale, Debasisa Mohant...
BMCBI
2007
117views more  BMCBI 2007»
13 years 5 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins