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BMCBI
2008
92views more  BMCBI 2008»
13 years 5 months ago
Proteochemometric modeling of HIV protease susceptibility
Background: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated ...
Maris Lapinsh, Martin Eklund, Ola Spjuth, Peteris ...
IJCNN
2006
IEEE
13 years 11 months ago
An Integrated Soft Computing Approach for Predicting Biological Activity of Potential HIV-1 Protease Inhibitors
Abstract— Using a neural network-fuzzy logic-genetic algorithm approach we generate an optimal predictor for biological activities of HIV-1 protease potential inhibitory compound...
Razvan Andonie, Levente Fabry-Asztalos, Sarah Abdu...
BIBE
2005
IEEE
116views Bioinformatics» more  BIBE 2005»
13 years 11 months ago
Stochastic Model of Protease-Ligand Reactions
Prediction of protein tertiary structure based on amino acid sequence is one of the most challenging open questions in computational molecular biology. The two most common experim...
Paul E. Anderson, Douglas W. Raiford, Deacon J. Sw...
BMCBI
2010
109views more  BMCBI 2010»
13 years 5 months ago
Pripper: prediction of caspase cleavage sites from whole proteomes
Background: Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate-...
Mirva Piippo, Niina Lietzén, Olli Nevalaine...
NAR
2007
235views more  NAR 2007»
13 years 5 months ago
PAR-3D: a server to predict protein active site residues
PAR-3D (http://sunserver.cdfd.org.in:8080/protease /PAR_3D/index.html) is a web-based tool that exploits the fact that relative juxtaposition of active site residues is a conserve...
Kshama Goyal, Debasisa Mohanty, Shekhar C. Mande