Background: A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated ...
Maris Lapinsh, Martin Eklund, Ola Spjuth, Peteris ...
Abstract— Using a neural network-fuzzy logic-genetic algorithm approach we generate an optimal predictor for biological activities of HIV-1 protease potential inhibitory compound...
Razvan Andonie, Levente Fabry-Asztalos, Sarah Abdu...
Prediction of protein tertiary structure based on amino acid sequence is one of the most challenging open questions in computational molecular biology. The two most common experim...
Paul E. Anderson, Douglas W. Raiford, Deacon J. Sw...
Background: Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate-...
PAR-3D (http://sunserver.cdfd.org.in:8080/protease /PAR_3D/index.html) is a web-based tool that exploits the fact that relative juxtaposition of active site residues is a conserve...