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ISMB
1994
13 years 6 months ago
Protein Design by Optimization of a Sequence-Structure Quality Function
Anautomatedprocedurefor protein designbyoptimization of a sequence-structurequalityhasbeendeveloped. Themethodselectsa statistically optimalsequencefor a particularstructure,onthe...
Steven E. Brenner, Alan Berry
BMCBI
2011
12 years 8 months ago
Determinants of Antigenicity and Specificity in immune response for Protein Sequences
Background: Target specific antibodies are pivotal for the design of vaccines, immunodiagnostic tests, studies on proteomics for cancer biomarker discovery, identification of prot...
Yulong Wang, Wenjun Wu, Nicolas N. Negre, Kevin P....
BMCBI
2008
114views more  BMCBI 2008»
13 years 4 months ago
Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design
Background: Protein structure prediction and computational protein design require efficient yet sufficiently accurate descriptions of aqueous solvent. We continue to evaluate the ...
Marcel Schmidt am Busch, Anne Lopes, Najette Amara...
BIBE
2007
IEEE
147views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
A New Alignment-Independent Algorithm for Clustering Protein Sequences
—The rapid burgeoning of available protein data makes the use of clustering within families of proteins increasingly important, the challenge is to identify subfamilies of evolut...
Abdellali Kelil, Shengrui Wang, Ryszard Brzezinski
NAR
2011
305views Computer Vision» more  NAR 2011»
12 years 7 months ago
CDD: a Conserved Domain Database for the functional annotation of proteins
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from...
Aron Marchler-Bauer, Shennan Lu, John B. Anderson,...