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13 years 6 months ago
Search for a New Description of Protein Topology and Local Structure
A novel description of protein structure in terms of the generalized secondary structure elements (GSSE) is proposed. GSSE's are defined as fragments of the protein structure...
Lukasz Jaroszewski, Adam Godzik
BIBE
2007
IEEE
152views Bioinformatics» more  BIBE 2007»
13 years 5 months ago
SBLAST: Structural Basic Local Alignment Searching Tools using Geometric Hashing
While much research has been done on finding similarities between protein sequences, there has not been the same progress on finding similarities between protein structures. Here ...
Tom Milledge, Gaolin Zheng, Tim Mullins, Giri Nara...
BMCBI
2007
128views more  BMCBI 2007»
13 years 4 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
BMCBI
2010
135views more  BMCBI 2010»
13 years 5 months ago
HDAPD: a web tool for searching the disease-associated protein structures
Background: The protein structures of the disease-associated proteins are important for proceeding with the structure-based drug design to against a particular disease. Up until n...
Yi-Ruen Lin, Hsin-Yuan Wei, Tsung-Lin Tsai, Thy-Ho...
GECCO
2008
Springer
164views Optimization» more  GECCO 2008»
13 years 5 months ago
Genetic algorithms with local search optimization for protein structure prediction problem
This paper presents a new Genetic Algorithm for Protein Structure Prediction problem in both 2D and 3D hydrophobichydrophilic lattice models, introduced in [1]. Our algorithm evol...
Igor Berenboym, Mireille Avigal