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BIB
2006
141views more  BIB 2006»
13 years 4 months ago
Statistical significance in biological sequence analysis
One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of ...
Alexander Yu. Mitrophanov, Mark Borodovsky
IDA
2007
Springer
13 years 10 months ago
Learning to Align: A Statistical Approach
We present a new machine learning approach to the inverse parametric sequence alignment problem: given as training examples a set of correct pairwise global alignments, find the p...
Elisa Ricci, Tijl De Bie, Nello Cristianini
RECOMB
2006
Springer
14 years 4 months ago
Alignment Statistics for Long-Range Correlated Genomic Sequences
It is well known that the base composition along eukaryotic genomes is long-range correlated. Here, we investigate the effect of such long-range correlations on alignment score sta...
Philipp W. Messer, Ralf Bundschuh, Martin Vingron,...
JCB
2007
107views more  JCB 2007»
13 years 4 months ago
Effects of Long-Range Correlations in DNA on Sequence Alignment Score Statistics
Long-range correlations in genomic base composition are a ubiquitous statistical feature among many eukaryotic genomes. In this article, these correlations are shown to substantia...
Philipp W. Messer, Ralf Bundschuh, Martin Vingron,...
JCB
2008
106views more  JCB 2008»
13 years 4 months ago
Statistics of Random Protein Superpositions: p-Values for Pairwise Structure Alignment
Quantification of statistical significance is essential for the interpretation of protein structural similarity. To address this, a random model for protein structure comparison w...
James O. Wrabl, Nick V. Grishin