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BMCBI
2010
150views more  BMCBI 2010»
13 years 4 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2006
194views more  BMCBI 2006»
13 years 4 months ago
Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
CIBCB
2006
IEEE
13 years 10 months ago
A Stochastic model to estimate the time taken for Protein-Ligand Docking
Abstract— Quantum mechanics and molecular dynamic simulation provide important insights into structural configurations and molecular interaction data today. To extend this atomi...
Preetam Ghosh, Samik Ghosh, Kalyan Basu, Sajal K. ...
BMCBI
2007
161views more  BMCBI 2007»
13 years 4 months ago
Efficient classification of complete parameter regions based on semidefinite programming
Background: Current approaches to parameter estimation are often inappropriate or inconvenient for the modelling of complex biological systems. For systems described by nonlinear ...
Lars Kuepfer, Uwe Sauer, Pablo A. Parrilo
TCS
2011
12 years 11 months ago
Parameter estimation for Boolean models of biological networks
Boolean networks have long been used as models of molecular networks and play an increasingly important role in systems biology. This paper describes a software package, offered ...
Elena S. Dimitrova, Luis David García-Puent...