Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Current biological sequence comparison tools frequently fail to recognize matches between homologs when sequence similarity is below the twilight zone of less than 25% sequence id...
COMPASS is a method for homology detection and local alignment construction based on the comparison of multiple sequence alignments (MSAs). The method derives numerical profiles f...
Ruslan Sadreyev, Ming Tang, Bong-Hyun Kim, Nick V....
Growing interest in genomic research has resulted in the creation of huge biological sequence databases. In this paper, we present a hash-based pier model for efficient homology s...
Xia Cao, Shuai Cheng Li, Beng Chin Ooi, Anthony K....
We present a novel approach to managing redundancy in sequence databanks such as GenBank. We store clusters of near-identical sequences as a representative union-sequence and a se...
Michael Cameron, Yaniv Bernstein, Hugh E. Williams