34 search results - page 2 / 7 » Suboptimal Alignments Improve the Detection of Weak Homologs... |
BMCBI
2005
13 years 5 months ago
2005
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
BIOCOMP
2009
2009
Improving Remote Homology Detection Using Sequence Properties and Position Specific Scoring Matrices
13 years 6 months ago
Current biological sequence comparison tools frequently fail to recognize matches between homologs when sequence similarity is below the twilight zone of less than 25% sequence id...
NAR
2007
13 years 4 months ago
2007
COMPASS is a method for homology detection and local alignment construction based on the comparison of multiple sequence alignments (MSAs). The method derives numerical profiles f...
SIGMOD
2004
ACM
14 years 5 months ago
2004
ACM
Growing interest in genomic research has resulted in the creation of huge biological sequence databases. In this paper, we present a hash-based pier model for efficient homology s...
JCB
2007
13 years 5 months ago
2007
We present a novel approach to managing redundancy in sequence databanks such as GenBank. We store clusters of near-identical sequences as a representative union-sequence and a se...