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RECOMB
2004
Springer
14 years 5 months ago
Multiple organism gene finding by collapsed gibbs sampling
The Gibbs sampling method has been widely used for sequence analysis after it was successfully applied to the problem of identifying regulatory motif sequences upstream of genes. ...
Sourav Chatterji, Lior Pachter
BMCBI
2007
114views more  BMCBI 2007»
13 years 5 months ago
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
Allegra Via, Pier Federico Gherardini, Enrico Ferr...
BMCBI
2010
124views more  BMCBI 2010»
13 years 5 months ago
Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated
Background: Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing met...
Norman E. Davey, Richard J. Edwards, Denis C. Shie...
CEC
2007
IEEE
13 years 11 months ago
A co-evolutionary framework for regulatory motif discovery
Abstract— In previous work, we have shown how an evolutionary algorithm with a clustered population can be used to concurrently discover multiple regulatory motifs present within...
Michael A. Lones, Andy M. Tyrrell
BMCBI
2006
103views more  BMCBI 2006»
13 years 5 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...