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RECOMB
2010
Springer
13 years 7 months ago
An Algorithmic Framework for Predicting Side-Effects of Drugs
Abstract. One of the critical stages in drug development is the identification of potential side effects for promising drug leads. Large scale clinical experiments aimed at discove...
Nir Atias, Roded Sharan
RECOMB
2010
Springer
14 years 15 days ago
Hierarchical Generative Biclustering for MicroRNA Expression Analysis
Clustering methods are a useful and common first step in gene expression studies, but the results may be hard to interpret. We bring in explicitly an indicator of which genes tie ...
José Caldas, Samuel Kaski
RECOMB
2010
Springer
13 years 4 months ago
Detecting Highways of Horizontal Gene Transfer
Abstract. In a horizontal gene transfer (HGT) event a gene is transferred between two species that do not share an ancestor-descendant relationship. Typically, no more than a few g...
Mukul S. Bansal, J. Peter Gogarten, Ron Shamir
RECOMB
2010
Springer
13 years 4 months ago
The Problem of Chromosome Reincorporation in DCJ Sorting and Halving
We study two problems in the double cut and join (DCJ) model: sorting – transforming one multilinear genome into another and halving – transforming a duplicated genome into a p...
Jakub Kovác, Marília D. V. Braga, Je...
RECOMB
2010
Springer
13 years 4 months ago
Limited Lifespan of Fragile Regions in Mammalian Evolution
An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Althou...
Max A. Alekseyev, Pavel A. Pevzner