BMCBI
2005
13 years 5 months ago
2005
Background: Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alter...
BMCBI
2005
13 years 5 months ago
2005
Background: One important application of microarray experiments is to identify differentially expressed genes. Often, small and negative expression levels were clipped-off to be e...
BMCBI
2005
13 years 5 months ago
2005
Background: The generation of large amounts of microarray data presents challenges for data collection, annotation, exchange and analysis. Although there are now widely accepted f...
BMCBI
2005
13 years 5 months ago
2005
Background: Chromosomal copy number changes (aneuploidies) play a key role in cancer progression and molecular evolution. These copy number changes can be studied using microarray...
BMCBI
2005
13 years 5 months ago
2005
The current methods of publishing chemical information in bioscience articles are analysed. Using 3 papers as use-cases, it is shown that conventional methods using human procedur...
BMCBI
2005
13 years 5 months ago
2005
Chemical information is now seen as critical for most areas of life sciences. But unlike Bioinformatics, where data is Openly available and freely re-usable, most chemical informa...
BMCBI
2005
13 years 5 months ago
2005
Background: In plants, RNA editing is a process that converts specific cytidines to uridines and uridines to cytidines in transcripts from virtually all mitochondrial protein-codi...
BMCBI
2005
13 years 5 months ago
2005
Background: Interpretation of simple microarray experiments is usually based on the fold-change of gene expression between a reference and a "treated" sample where the t...
BMCBI
2005
13 years 5 months ago
2005
Background: The large amount of data that are currently produced in the biological sciences can no longer be explored and visualized efficiently with traditional, specialized soft...
BMCBI
2005
13 years 5 months ago
2005
Computational Biology needs computer-readable information records. Increasingly, meta-analysed and pre-digested information is being used in the follow up of high throughput exper...