BMCBI
2005
13 years 5 months ago
2005
Background: Gene expression programs depend on recognition of cis elements in promoter region of target genes by transcription factors (TFs), but how TFs regulate gene expression ...
BMCBI
2005
13 years 5 months ago
2005
: One of the most evident achievements of bioinformatics is the development of methods that transfer biological knowledge from characterised proteins to uncharacterised sequences. ...
BMCBI
2005
13 years 5 months ago
2005
Background: The use of mass spectrometry as a proteomics tool is poised to revolutionize early disease diagnosis and biomarker identification. Unfortunately, before standard super...
BMCBI
2005
13 years 5 months ago
2005
BMCBI
2005
13 years 5 months ago
2005
Background: The large gap between the number of protein sequences in databases and the number of functionally characterized proteins calls for the development of a fast computatio...
BMCBI
2005
13 years 5 months ago
2005
Background: The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico. Recently there has been an ...
BMCBI
2005
13 years 5 months ago
2005
Background: Microarray experiments, as well as other genomic analyses, often result in large gene sets containing up to several hundred genes. The biological significance of such ...
BMCBI
2005
13 years 5 months ago
2005
Background: It is common for the results of a microarray study to be analyzed in the context of biologically-motivated groups of genes such as pathways or Gene Ontology categories...
BMCBI
2005
13 years 5 months ago
2005
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
BMCBI
2005
13 years 5 months ago
2005
Background: Users of microarray technology typically strive to use universally acceptable data analysis strategies to determine significant expression changes in their experiments...