BMCBI
2005
13 years 4 months ago
2005
Background: Improvements in protein sequence annotation and an increase in the number of annotated protein databases has fueled development of an increasing number of software too...
BMCBI
2005
13 years 4 months ago
2005
Background: The analysis of biological data is greatly enhanced by existing or emerging databases. Most existing databases, with few exceptions are not designed to easily support ...
BMCBI
2005
13 years 4 months ago
2005
Background: Gene set enrichment analysis (GSEA) is a microarray data analysis method that uses predefined gene sets and ranks of genes to identify significant biological changes i...
BMCBI
2005
13 years 4 months ago
2005
Background: Translational research requires taking basic science observations and developing them into clinically useful tests and therapeutics. We have developed a process to dev...
BMCBI
2005
13 years 4 months ago
2005
Background: Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profi...
BMCBI
2005
13 years 4 months ago
2005
Background: In two-channel competitive genomic hybridization microarray experiments, the ratio of the two fluorescent signal intensities at each spot on the microarray is commonly...
BMCBI
2005
13 years 4 months ago
2005
Background: Liquid chromatography coupled to mass spectrometry (LC/MS) has been widely used in proteomics and metabolomics research. In this context, the technology has been incre...
BMCBI
2005
13 years 4 months ago
2005
Background: Computational protein annotation methods occasionally introduce errors. Falsepositive (FP) errors are annotations that are mistakenly associated with a protein. Such f...
BMCBI
2005
13 years 4 months ago
2005
Background: In the post-genomic era, correct gene prediction has become one of the biggest challenges in genome annotation. Improved promoter prediction methods can be one step to...
BMCBI
2005
13 years 4 months ago
2005
Background: Several data formats have been developed for large scale biological experiments, using a variety of methodologies. Most data formats contain a mechanism for allowing e...