BMCBI
2007
13 years 5 months ago
2007
Background: Extracting biological information from high-density Affymetrix arrays is a multi-step process that begins with the accurate annotation of microarray probes. Shortfalls...
BMCBI
2007
13 years 5 months ago
2007
Background: Although many genomic features have been used in the prediction of proteinprotein interactions (PPIs), frequently only one is used in a computational method. After rea...
BMCBI
2007
13 years 5 months ago
2007
Background: Automated methods for assembling families of orthologous genes include those based on sequence similarity scores and those based on phylogenetic approaches. The first ...
BMCBI
2007
13 years 5 months ago
2007
BMCBI
2007
13 years 5 months ago
2007
Background: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To ...
BMCBI
2007
13 years 5 months ago
2007
Background: Gene Set Enrichment Analysis (GSEA) is a computational method for the statistical evaluation of sorted lists of genes or proteins. Originally GSEA was developed for in...
BMCBI
2007
13 years 5 months ago
2007
Background: The task of computing highly accurate structural alignments of proteins in very short computation time is still challenging. This is partly due to the complexity of pr...
BMCBI
2007
13 years 5 months ago
2007
Background: An ever increasing number of techniques are being used to find genes with similar profiles from microarray studies. Visualization of gene expression profiles can aid t...
BMCBI
2007
13 years 5 months ago
2007
Background: For many metalloproteins, sequence motifs characteristic of metal-binding sites have not been found or are so short that they would not be expected to be metal-specifi...
BMCBI
2007
13 years 5 months ago
2007
Background: In Archeae and Bacteria, the repeated elements called CRISPRs for "clustered regularly interspaced short palindromic repeats" are believed to participate in ...