BMCBI
2007
13 years 4 months ago
2007
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
BMCBI
2007
13 years 4 months ago
2007
Background: Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavio...
BMCBI
2007
13 years 4 months ago
2007
Background: Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions i...
BMCBI
2007
13 years 4 months ago
2007
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
BMCBI
2007
13 years 4 months ago
2007
Background: The study of microRNAs (miRNAs) is attracting great considerations. Recent studies revealed that miRNAs play as important regulators of gene expression and some even a...
BMCBI
2007
13 years 4 months ago
2007
Background: An indirect approach is usually used to estimate the metabolic fluxes of an organism: couple the available measurements with known biological constraints (e.g. stoichi...
BMCBI
2007
13 years 4 months ago
2007
Background: The underlying goal of microarray experiments is to identify gene expression patterns across different experimental conditions. Genes that are contained in a particula...
BMCBI
2007
13 years 4 months ago
2007
Background: Clustering methods are widely used on gene expression data to categorize genes with similar expression profiles. Finding an appropriate (dis)similarity measure is crit...
BMCBI
2007
13 years 4 months ago
2007
Background: The study of the functional role of alternative splice isoforms of a gene is a very active area of research in biology. The difficulty of the experimental approach (in...
BMCBI
2007
13 years 4 months ago
2007
Background: The definition of a distance measure plays a key role in the evaluation of different clustering solutions of gene expression profiles. In this empirical study we compa...