BMCBI
2008
13 years 5 months ago
2008
Background: Establishment of peptide binding to Major Histocompatibility Complex class I (MHCI) is a crucial step in the development of subunit vaccines and prediction of such bin...
BMCBI
2008
13 years 5 months ago
2008
Background: We have developed a new computational algorithm, Shape-IT, to infer haplotypes under the genetic model of coalescence with recombination developed by Stephens et al in...
BMCBI
2008
13 years 5 months ago
2008
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
BMCBI
2008
13 years 5 months ago
2008
Background: Multifactor Dimensionality Reduction (MDR) has been introduced previously as a non-parametric statistical method for detecting gene-gene interactions. MDR performs a d...
BMCBI
2008
13 years 5 months ago
2008
Background: Gene Ontology (GO) annotation, which describes the function of genes and gene products across species, has recently been used to predict protein subcellular and subnuc...
BMCBI
2008
13 years 5 months ago
2008
Background: Microarray analysis allows the simultaneous measurement of thousands to millions of genes or sequences across tens to thousands of different samples. The analysis of t...
BMCBI
2008
13 years 5 months ago
2008
Background: Similarity inference, one of the main bioinformatics tasks, has to face an exponential growth of the biological data. A classical approach used to cope with this data ...
BMCBI
2008
13 years 5 months ago
2008
BMCBI
2008
13 years 5 months ago
2008
Background: Spatially mapped large scale gene expression databases enable quantitative comparison of data measurements across genes, anatomy, and phenotype. In most ongoing effort...
BMCBI
2008
13 years 5 months ago
2008
Background: Detecting conserved noncoding sequences (CNSs) across species highlights the functional elements. Alignment procedures combined with computational prediction of transc...