BMCBI
2008
13 years 5 months ago
2008
Background: The problem of accurate prediction of protein secondary structure continues to be one of the challenging problems in Bioinformatics. It has been previously suggested t...
BMCBI
2008
13 years 5 months ago
2008
Background: Proteomic profiling using mass spectrometry (MS) is one of the most promising methods for the analysis of complex biological samples such as urine, serum and tissue fo...
BMCBI
2008
13 years 5 months ago
2008
Background: The Signal-to-Noise-Ratio (SNR) is often used for identification of biomarkers for two-class problems and no formal and useful generalization of SNR is available for m...
BMCBI
2008
13 years 5 months ago
2008
Background: Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aber...
BMCBI
2008
13 years 5 months ago
2008
BMCBI
2008
13 years 5 months ago
2008
Background: Nonnegative matrix factorization (NMF) is a feature extraction method that has the property of intuitive part-based representation of the original features. This uniqu...
BMCBI
2008
13 years 5 months ago
2008
Background: Repeat-induced point mutation (RIP) is a fungal-specific genome defence mechanism that alters the sequences of repetitive DNA, thereby inactivating coding genes. Repea...
BMCBI
2008
13 years 5 months ago
2008
Background: Since experimental determination of protein folding pathways remains difficult, computational techniques are often used to simulate protein folding. Most current techn...
BMCBI
2008
13 years 5 months ago
2008
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
BMCBI
2008
13 years 5 months ago
2008
Background: It has repeatedly been shown that interacting protein families tend to have similar phylogenetic trees. These similarities can be used to predicting the mapping betwee...