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BMCBI
2008
120views more  BMCBI 2008»
13 years 4 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...
BMCBI
2008
125views more  BMCBI 2008»
13 years 4 months ago
Disambiguation of biomedical text using diverse sources of information
Background: Like text in other domains, biomedical documents contain a range of terms with more than one possible meaning. These ambiguities form a significant obstacle to the aut...
Mark Stevenson, Yikun Guo, Robert J. Gaizauskas, D...
BMCBI
2008
115views more  BMCBI 2008»
13 years 4 months ago
PARPST: a PARallel algorithm to find peptide sequence tags
Background: Protein identification is one of the most challenging problems in proteomics. Tandem mass spectrometry provides an important tool to handle the protein identification ...
Sara Brunetti, Elena Lodi, Elisa Mori, Maria Stell...
BMCBI
2008
122views more  BMCBI 2008»
13 years 4 months ago
A practical comparison of two K-Means clustering algorithms
Background: Data clustering is a powerful technique for identifying data with similar characteristics, such as genes with similar expression patterns. However, not all implementat...
Gregory A. Wilkin, Xiuzhen Huang
BMCBI
2008
77views more  BMCBI 2008»
13 years 4 months ago
Stochastic models for the in silico simulation of synaptic processes
Background: Research in life sciences is benefiting from a large availability of formal description techniques and analysis methodologies. These allow both the phenomena investiga...
Andrea Bracciali, Marcello Brunelli, Enrico Catald...
BMCBI
2008
125views more  BMCBI 2008»
13 years 4 months ago
Competition between protein aggregation and protein complex formation
ent> <title> <p>Highlights from the Fourth International Society for Computational Biology (ISCB) Student Council Symposium</p> </title> <editor>Lu...
Sebastian Pechmann, Emmanuel D. Levy, Gian G. Tart...
BMCBI
2008
133views more  BMCBI 2008»
13 years 4 months ago
Towards ontology-driven navigation of the lipid bibliosphere
Background: The indexing of scientific literature and content is a relevant and contemporary requirement within life science information systems. Navigating information available ...
Christopher J. O. Baker, Kanagasabai Rajaraman, We...
BMCBI
2008
116views more  BMCBI 2008»
13 years 4 months ago
Gene Ontology annotations: what they mean and where they come from
To address the challenges of information integration and retrieval, the computational genomics community increasingly has come to rely on the methodology of creating annotations o...
David P. Hill, Barry Smith, Monica S. McAndrews-Hi...
BMCBI
2008
85views more  BMCBI 2008»
13 years 4 months ago
Wanted: unique names for unique atom positions. PDB-wide analysis of diastereotopic atom names of small molecules containing dip
Background: Biological chemistry is very stereospecific. Nonetheless, the diastereotopic oxygen atoms of diphosphate-containing molecules in the Protein Data Bank (PDB) are often ...
Christopher A. Bottoms, Dong Xu
BMCBI
2008
62views more  BMCBI 2008»
13 years 4 months ago
Filtering of false positive microRNA candidates by a clustering-based approach
Background: MicroRNAs are small non-coding RNA gene products that play diversified roles from species to species. The explosive growth of microRNA researches in recent years prove...
Wing-Sze Leung, Marie C. M. Lin, David Wai-Lok Che...