BMCBI
2008
13 years 4 months ago
2008
Background: Understanding how genes are expressed and regulated in different tissues is a fundamental and challenging question. However, most of currently available biological dat...
BMCBI
2008
13 years 4 months ago
2008
Background: In cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: r...
BMCBI
2008
13 years 4 months ago
2008
Background: Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STRUCTURE and L-POP, usually ass...
BMCBI
2008
13 years 4 months ago
2008
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...
BMCBI
2008
13 years 4 months ago
2008
Background: Sequences and structures provide valuable complementary information on protein features and functions. However, it is not always straightforward for users to gather in...
BMCBI
2008
13 years 4 months ago
2008
Background: R is the preferred tool for statistical analysis of many bioinformaticians due in part to the increasing number of freely available analytical methods. Such methods ca...
BMCBI
2008
13 years 4 months ago
2008
Background: We propose a multiple sequence alignment (MSA) algorithm and compare the alignment-quality and execution-time of the proposed algorithm with that of existing algorithm...
BMCBI
2008
13 years 4 months ago
2008
BMCBI
2008
13 years 4 months ago
2008
Background: The increasing availability of fungal genome sequences provides large numbers of proteins for evolutionary and phylogenetic analyses. However the heterogeneity of data...
BMCBI
2008
13 years 4 months ago
2008
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...