BMCBI
2011
13 years 6 days ago
2011
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
BMCBI
2011
13 years 6 days ago
2011
Background: Alternative splicing (AS) is a process which generates several distinct mRNA isoforms from the same gene by splicing different portions out of the precursor transcript...
BMCBI
2011
13 years 6 days ago
2011
Background: Tiling array data is hard to interpret due to noise. The wavelet transformation is a widely used technique in signal processing for elucidating the true signal from no...
BMCBI
2011
13 years 6 days ago
2011
Background: As the canonical code is not universal, different theories about its origin and organization have appeared. The optimization or level of adaptation of the canonical ge...
BMCBI
2011
13 years 6 days ago
2011
Background: Tumor cells are considered to have an aberrant cell state, and some evidence indicates different development states appearing in the tumorigenesis. Embryonic developme...
BMCBI
2011
13 years 6 days ago
2011
Background: The analysis of protein structures provides fundamental insight into most biochemical functions and consequently into the cause and possible treatment of diseases. As ...
BMCBI
2011
13 years 6 days ago
2011
Background: Cluster analysis is a crucial tool in several biological and medical studies dealing with microarray data. Such studies pose challenging statistical problems due to di...
BMCBI
2011
13 years 6 days ago
2011
Background: Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of environmental samples. Because of the diver...
BMCBI
2011
13 years 6 days ago
2011
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
BMCBI
2011
13 years 6 days ago
2011
Background: In many environmental genomics applications a homologous region of DNA from a diverse sample is first amplified by PCR and then sequenced. The next generation sequenci...