BMCBI
2008
13 years 5 months ago
2008
Background: High throughput microarray technologies have afforded the investigation of genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software packa...
BMCBI
2008
13 years 5 months ago
2008
Background: The hierarchical clustering tree (HCT) with a dendrogram [1] and the singular value decomposition (SVD) with a dimension-reduced representative map [2] are popular met...
BMCBI
2008
13 years 5 months ago
2008
Background: Temporal gene expression profiles characterize the time-dynamics of expression of specific genes and are increasingly collected in current gene expression experiments....
BMCBI
2008
13 years 5 months ago
2008
Background: Microarray technology has become very popular for globally evaluating gene expression in biological samples. However, non-linear variation associated with the technolo...
BMCBI
2008
13 years 5 months ago
2008
Background: Microarray techniques are one of the main methods used to investigate thousands of gene expression profiles for enlightening complex biological processes responsible f...
BMCBI
2007
13 years 5 months ago
2007
Background: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccur...
BMCBI
2007
13 years 5 months ago
2007
Background: A major goal of computational studies of gene regulation is to accurately predict the expression of genes based on the cis-regulatory content of their promoters. The d...
BMCBI
2008
13 years 5 months ago
2008
Background: High-density short oligonucleotide microarrays are a primary research tool for assessing global gene expression. Background noise on microarrays comprises a significan...
BMCBI
2008
13 years 5 months ago
2008
Background: Microarray gene expression data are often analyzed together with corresponding physiological response and clinical metadata of biological subjects, e.g. patients'...
BMCBI
2008
13 years 5 months ago
2008
Background: The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, ...