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ISMB
1998
8 years 5 months ago
Automated Clustering and Assembly of Large EST Collections
The avMlability of large EST(Expressed Sequence Tag)databases has led to a revolution in the waynew genes are cloned. Difficulties arise, however,due to high error rates and redun...
David P. Yee, Darrell Conklin
ISMB
1998
8 years 5 months ago
Genetic Algorithms for Protein Threading
Jacqueline Yadgari, Amihood Amir, Ron Unger
ISMB
1998
8 years 5 months ago
Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...
Imran Shah, Lawrence Hunter
ISMB
1998
8 years 5 months ago
A Surface Measure for Probabilistic Structural Computations
Computingthree-dimensional structures from sparse experimentalconstraints requires methodsfor combining heterogeneoussourcesof information,such as distances, angles, andmeasuresof...
Jeanette P. Schmidt, Cheng Che Chen, Jonathan L. C...
ISMB
1998
8 years 5 months ago
Sequence Assembly Validation by Multiple Restriction Digest Fragment Coverage Analysis
DNA sequence analysis depends on the accurate assembly of fragment reads for the determination of a consensus sequence. This report examines the possibility of analyzing multiple,...
Eric C. Rouchka, David J. States
ISMB
1998
8 years 5 months ago
A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences
A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an a...
Erik L. L. Sonnhammer, Gunnar von Heijne, Anders K...
ISMB
1998
8 years 5 months ago
Bayesian Protein Family Classifier
A Bayesian procedure for the simultaneous alignment and classification of sequences into subclasses is described. This Gibbs sampling algorithm iterates between an alignment step ...
Kunbin Qu, Lee Ann McCue, Charles E. Lawrence
ISMB
1998
8 years 5 months ago
Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains
This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...
Kimmen Sjölander
ISMB
1998
8 years 5 months ago
Segment-Based Scores for Pairwise and Multiple Sequence Alignments
Burkhard Morgenstern, William R. Atchley, Klaus Ha...
ISMB
1998
8 years 5 months ago
Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model
A hidden Markov model of signal peptides has been developed. It contains submodels for the N-terminal part, the hydrophobic region, and the region around the cleavage site. For kn...
Henrik Nielsen, Anders Krogh
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