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ISMB
1998
9 years 20 days ago
Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
Wedescribe a prototype system (Poly-X) for assisting an expert user in modelingprotein repeats. Poly-X reduces the large numberof degrees of freedomrequired to specify a protein m...
Richard H. Lathrop, Malcolm S. Casale, Douglas J. ...
ISMB
1998
9 years 20 days ago
The LabFlow System for Workflow Management in Large Scale Biology Research Laboratories
LabFlowis a workflowmanagementsystem designed for large scale biologyresearch laboratories. It providesa workflowmodelin whichobjects flowfromtask to task under programmaticcontro...
Nathan Goodman, Steve Rozen, Lincoln Stein
ISMB
1998
9 years 20 days ago
BioSim: A New Qualitative Simulation Environment for Molecular Biology
Traditionally, biochemical systems are modelled usingkinetics anddifferential equationsin a quantitative simulator. However,for manybiological processes detailed quantitative info...
Karsten R. Heidtke, Steffen Schulze-Kremer
ISMB
1998
9 years 20 days ago
A Statistical Theory of Sequence Alignment with Gaps
Astatistical theory of local alignmentalgorithms with gaps is presented. Both the linear and logarithmic phases, as well as the phase transition separating the two phases, are des...
Dirk Drasdo, Terence Hwa, Michael Lässig
ISMB
1998
9 years 20 days ago
Advanced Query Mechanisms for Biological Databases
Existing query interfaces for biological databases are either based on fixed forms or textual query languages. Users of a fixed form-based query interface are limited to performin...
I-Min A. Chen, Anthony Kosky, Victor M. Markowitz,...
ISMB
1998
9 years 20 days ago
Computational Applications of DNA Structural Scales
We study from a computational standpoint several different physicalscales associatedwith structural features of DNA sequences, including dinucleotide scales such as base stacking ...
Pierre Baldi, Søren Brunak, Yves Chauvin, A...
ISMB
1998
9 years 20 days ago
Compression of Strings with Approximate Repeats
We describe a model for strings of characters that is loosely based on the Lempel Ziv model with the addition that a repeated substring can be an approximate match to the original...
Lloyd Allison, Timothy Edgoose, Trevor I. Dix
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