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RECOMB
2002
Springer
10 years 1 months ago
Deconvolving sequence variation in mixed DNA populations
We present an original approach to identifying sequence variants in a mixed DNA population from sequence trace data. The heart of the method is based on parsimony: given a wildtyp...
Andy Wildenberg, Steven Skiena, Pavel Sumazin
RECOMB
2002
Springer
10 years 1 months ago
A dimensionality reduction approach to modeling protein flexibility
Proteins are involved either directly or indirectly in all biological processes in living organisms. It is now widely accepted that conformational changes of proteins can critical...
Miguel L. Teodoro, George N. Phillips, Lydia E. Ka...
RECOMB
2002
Springer
10 years 1 months ago
Probabilistic hierarchical clustering for biological data
Biological data, such as gene expression profiles or protein sequences, is often organized in a hierarchy of classes, where the instances assigned to "nearby" classes in...
Eran Segal, Daphne Koller
RECOMB
2002
Springer
10 years 1 months ago
From promoter sequence to expression: a probabilistic framework
We present a probabilistic framework that models the process by which transcriptional binding explains the mRNA expression of different genes. Our joint probabilistic model unifie...
Eran Segal, Yoseph Barash, Itamar Simon, Nir Fried...
RECOMB
2002
Springer
10 years 1 months ago
String barcoding: uncovering optimal virus signatures
There are many critical situations when one needs to rapidly identify an unidentified pathogen from among a given set of previously sequenced pathogens. DNA or RNA hybridization c...
Sam Rash, Dan Gusfield
RECOMB
2002
Springer
10 years 1 months ago
Revealing protein structures: a new method for mapping antibody epitopes
A recent idea for determining the three-dimensional structure of a protein uses antibody recognition of surface structure and random peptide libraries to map antibody epitope comb...
Brendan Mumey, Brian W. Bailey, Edward A. Dratz
RECOMB
2002
Springer
10 years 1 months ago
Combining pairwise sequence similarity and support vector machines for remote protein homology detection
One key element in understanding the molecular machinery of the cell is to understand the meaning, or function, of each protein encoded in the genome. A very successful means of i...
Li Liao, William Stafford Noble
RECOMB
2002
Springer
10 years 1 months ago
Phase-independent rhythmic analysis of genome-wide expression patterns
We introduce a model-based analysis technique for extracting and characterizing rhythmic expression pro les from genome-wide DNA microarray hybridization data. These patterns are ...
Christopher James Langmead, Anthony K. Yan, C. Rob...
RECOMB
2002
Springer
10 years 1 months ago
Finding motifs in the twilight zone
We introduce the notion of a multiprofile and use it for finding subtle motifs in DNA sequences. Multiprofiles generalize the notion of a profile and allow one to detect subtle co...
Uri Keich, Pavel A. Pevzner
RECOMB
2002
Springer
10 years 1 months ago
Approximate matching of secondary structures
This talk presents an algorithm to search for all approximate matches of a helix in a genome, where a helix is a combination of sequence and folding constraints. It is a joint wor...
Nadia El-Mabrouk, Mathieu Raffinot
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