An integrated approach to the prediction of domain-domain interactions

Background: The development of high-throughput technologies has produced several large scale protein interaction data sets for multiple species, and significant efforts have been made to analyze the data sets in order to understand protein activities. Considering that the basic units of protein interactions are domain interactions, it is crucial to understand protein interactions at the level of the domains. The availability of many diverse biological data sets provides an opportunity to discover the underlying domain interactions within protein interactions through an integration of these biological data sets. Results: We combine protein interaction data sets from multiple species, molecular sequences, and gene ontology to construct a set of high-confidence domain-domain interactions. First, we propose a new measure, the expected number of interactions for each pair of domains, to score domain interactions based on protein interaction data in one species and show that it has similar ...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Hyunju Lee, Minghua Deng, Fengzhu Sun, Ting Chen
• Keywords: BMCBI 2006, Domain Interactions, Protein Interaction, Protein Interaction Data