Genome wide prediction of protein function via a generic knowledge discovery approach based on evidence integration

Background: The automation of many common molecular biology techniques has resulted in the accumulation of vast quantities of experimental data. One of the major challenges now facing researchers is how to process this data to yield useful information about a biological system (e.g. knowledge of genes and their products, and the biological roles of proteins, their molecular functions, localizations and interaction networks). We present a technique called Global Mapping of Unknown Proteins (GMUP) which uses the Gene Ontology Index to relate diverse sources of ntal data by creation of an abstraction layer of evidence data. This abstraction layer is used as input to a neural network which, once trained, can be used to predict function from the evidence data of unannotated proteins. The method allows us to include almost any experimental data set related to protein function, which incorporates the Gene Ontology, to our evidence data in order to seek relationships between the different set...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Jianghui Xiong, Simon Rayner, Kunyi Luo, Yinghui Li, Shanguang Chen
• Keywords: BMCBI 2006, Evidence Data, Gene Ontology, Protein