Noise-injected neural networks show promise for use on small-sample expression data

Background: Overfitting the data is a salient issue for classifier design in small-sample settings. This is why selecting a classifier from a constrained family of classifiers, ones that do not possess the potential to too finely partition the feature space, is typically preferable. But overfitting is not merely a consequence of the classifier family; it is highly dependent on the classification rule used to design a classifier from the sample data. Thus, it is possible to consider families that are rather complex but for which there are classification rules that perform well for small samples. Such classification rules can be advantageous because they facilitate satisfactory classification when the class-conditional distributions are not easily separated and the sample is not large. Here we consider neural networks, from the perspectives of classical design based solely on the sample data and from noise-injection-based design. Results: This paper provides an extensive simulation-base...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Jianping Hua, James Lowey, Zixiang Xiong, Edward R. Dougherty
• Keywords: BMCBI 2006, Classification Rules, Design, Neural-network Design