Module locking in biochemical synthesis

—We are developing a framework for computation with biochemical reactions with a focus on synthesizing specific logical functionality, a task analogous to technology-independent logic synthesis. Our method synthesizes biochemical reactions that compute output quantities of molecular types as a function of input quantities, either deterministically or probabilistically. An important constraint is the timing, captured in the relative rates of the biochemical reactions: all the outputs of a given phase must be produced before the next phase can begin consuming them as inputs. To achieve this synchronization, the reaction rates must sometimes be separated by orders of magnitude: some much faster than others, some much slower. This might be costly or infeasible given a specific library of biochemical reactions. In this paper, we describe a novel mechanism for locking the computation of biochemical modules – analogous to handshaking mechanisms in asynchronous circuit design. With locki...

• Type: Conference
• Year: 2008
• Where: ICCAD
• Authors: Brian Fett, Marc D. Riedel
• Keywords: Biochemical Modules, Biochemical Reactions, Hardware, ICCAD 2008, Probabilistic Computation