Module locking in biochemical synthesis

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Module locking in biochemical synthesis
—We are developing a framework for computation with biochemical reactions with a focus on synthesizing specific logical functionality, a task analogous to technology-independent logic synthesis. Our method synthesizes biochemical reactions that compute output quantities of molecular types as a function of input quantities, either deterministically or probabilistically. An important constraint is the timing, captured in the relative rates of the biochemical reactions: all the outputs of a given phase must be produced before the next phase can begin consuming them as inputs. To achieve this synchronization, the reaction rates must sometimes be separated by orders of magnitude: some much faster than others, some much slower. This might be costly or infeasible given a specific library of biochemical reactions. In this paper, we describe a novel mechanism for locking the computation of biochemical modules – analogous to handshaking mechanisms in asynchronous circuit design. With locki...
Brian Fett, Marc D. Riedel
Added 16 Mar 2010
Updated 16 Mar 2010
Type Conference
Year 2008
Authors Brian Fett, Marc D. Riedel
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