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BCB
2010

A novel network model for molecular prognosis

9 years 3 months ago
A novel network model for molecular prognosis
Network-based genome-wide association studies (NWAS) utilize the molecular interactions between genes and functional pathways in biomarker identification. This study presents a novel network-based methodology for identifying prognostic gene signatures to predict cancer recurrence. The methodology contains the following steps: 1) Constructing genome-wide coexpression networks for different disease states (metastatic vs. nonmetastatic). Prediction logic is used to induct valid implication relations between each pair of gene expression profiles in terms of formal logic rules. 2) Identifying differential components associated with specific disease states from the genome-wide coexpression networks. 3) Dissecting network modules that are tightly connected with major disease signal hallmarks from the disease specific differential components. 4) Identifying most significant genes/probes associated with clinical outcome from the pathway connected network modules. Using this methodology, a 14-g...
Ying-Wooi Wan, Swetha Bose, James Denvir, Nancy La
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2010
Where BCB
Authors Ying-Wooi Wan, Swetha Bose, James Denvir, Nancy Lan Guo
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