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2007

PROMALS web server for accurate multiple protein sequence alignments

8 years 9 months ago
PROMALS web server for accurate multiple protein sequence alignments
Multiple sequence alignments are essential in homology inference, structure modeling, functional prediction and phylogenetic analysis. We developed a web server that constructs multiple protein sequence alignments using PROMALS, a progressive method that improves alignment quality by using additional homologs from PSI-BLAST searches and secondary structure predictions from PSIPRED. PROMALS shows higher alignment accuracy than other advanced methods, such as MUMMALS, ProbCons, MAFFT and SPEM. The PROMALS web server takes FASTA format protein sequences as input. The output includes a colored alignment augmented with information about sequence grouping, predicted secondary structures and positional conservation. The PROMALS web server is available at: http://prodata.swmed.edu/ promals/.
Jimin Pei, Bong-Hyun Kim, Ming Tang, Nick V. Grish
Added 27 Dec 2010
Updated 27 Dec 2010
Type Journal
Year 2007
Where NAR
Authors Jimin Pei, Bong-Hyun Kim, Ming Tang, Nick V. Grishin
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