Properties and identification of antibiotic drug targets

11 years 8 months ago
Properties and identification of antibiotic drug targets
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E. coli to identify differences in their properties and to predict new potential drug targets. Results: When compared to non-targets, bacterial antibiotic targets tend to be long, have high -sheet and low -helix contents, are polar, are found in the cytoplasm rather than in membranes, and are usually enzymes, with ligases particularly favoured. Sequence features were used to build a support vector machine model for E. coli proteins, allowing the assignment of any sequence to the drug target or non-target classes, with an accuracy in the training set of 94%. We identified 319 proteins (7%) in the non-target set that have target-like properties, many of which have unknown function. 63 of these proteins have significant and undesirable similarity to a human protein, leaving 256 target like proteins that are not present in hu...
Tala Bakheet, Andrew J. Doig
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2010
Authors Tala Bakheet, Andrew J. Doig
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