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BMCBI
2007

Relating destabilizing regions to known functional sites in proteins

8 years 8 months ago
Relating destabilizing regions to known functional sites in proteins
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relatives. Another limitation of these methods is the lack of a well annotated set of functional sites to use as benchmark for validating their predictions. Experimental findings and theoretical considerations suggest that residues involved in function often contribute unfavorably to the native state stability. We examine the possibility of systematically exploiting this intrinsic property to identify functional sites using an original procedure that detects destabilizing regions in protein structures. In addition, to relate destabilizing regions to known functional sites, a novel benchmark consisting of a diverse set of hand-curated protein functional sites is derived. Results: A procedure for detecting clusters of destabilizing residues in protein structures is presented. Individual residue contributions to protein...
Benoit H. Dessailly, Marc F. Lensink, Shoshana J.
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Benoit H. Dessailly, Marc F. Lensink, Shoshana J. Wodak
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