Towards Site-Based Protein Functional Annotations

11 years 3 months ago
Towards Site-Based Protein Functional Annotations
Abstract—The exact relationship between protein active centers and protein functions is unclear even after decades of intensive study. To improve the functional prediction ability based on the local protein structures, we proposed three different methods. 1) We used statistical model (known as Markov Random Field) to describe protein active region based on the structure motifs. 2) We developd a filter that considers the local environment around the active sites to remove the false positives. 3) we created multiple structure motifs by extending the motif to neighboring residues for delineating their functions. Our experimental results, as evaluated in five sets of enzyme families with less than 40% sequence identity, demonstrated that our methods can obtain more remote homologs that could not be detected by traditional sequence-based methods. At the same time, our method could reduce large amount of random matches. Our methods could improve up to 70 % of the functional annotation ab...
Seak Fei Lei, Jun Huan
Added 29 May 2010
Updated 29 May 2010
Type Conference
Year 2008
Where BIBM
Authors Seak Fei Lei, Jun Huan
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