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2008

RNALogo: a new approach to display structural RNA alignment

8 years 12 months ago
RNALogo: a new approach to display structural RNA alignment
Regulatory RNAs play essential roles in many essential biological processes, ranging from gene regulation to protein synthesis. This work presents a web-based tool, RNALogo, to create a new graphical representation of the patterns in a multiple RNA sequence alignment with a consensus structure. The RNALogo graph can indicate significant features within an RNA sequence alignment and its consensus RNA secondary structure. RNALogo extends Sequence logos, and specifically incorporates RNA secondary structures and mutual information of base-paired regions into the graphical representation. Each RNALogo graph is composed of stacks of letters, with one stack for each position in the consensus RNA secondary structure. RNALogo provides a convenient and high configurable logo generator. An RNALogo graph is generated for each RNA family in Rfam, and these generated logos are accumulated into a gallery of RNALogo. Users can search or browse RNALogo graphs in this gallery to receive additional per...
Tzu-Hao Chang, Jorng-Tzong Horng, Hsien-Da Huang
Added 28 Jan 2011
Updated 28 Jan 2011
Type Journal
Year 2008
Where NAR
Authors Tzu-Hao Chang, Jorng-Tzong Horng, Hsien-Da Huang
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