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BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
14 years 14 days ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber
BMCBI
2007
102views more  BMCBI 2007»
13 years 5 months ago
Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
RECOMB
2003
Springer
14 years 6 months ago
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals
We propose a framework for modeling sequence motifs based on the maximum entropy principle (MEP). We recommend approximating short sequence motif distributions with the maximum en...
Gene W. Yeo, Christopher B. Burge
DNA
2005
Springer
128views Bioinformatics» more  DNA 2005»
13 years 11 months ago
Recognizing DNA Splicing
Abstract. Motivated by recent techniques developed for observing evolutionary dynamics of a single DNA molecule, we introduce a formal model for accepting an observed behavior of a...
Matteo Cavaliere, Natasa Jonoska, Peter Leupold