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CIBCB
2008
IEEE
13 years 12 months ago
Discovering novel cancer therapies: A computational modeling and search approach
— Solid tumors must recruit new blood vessels for growth and maintenance. Discovering drugs that block this tumor-induced development of new blood vessels (angiogenesis) is an im...
Arthur W. Mahoney, Brian G. Smith, Nicholas S. Fla...
CONSTRAINTS
2011
12 years 9 months ago
CP and IP approaches to cancer radiotherapy delivery optimization
Abstract. We consider the problem of decomposing an integer matrix into a positively weighted sum of binary matrices that have the consecutive-ones property. This problem is well-k...
Davaatseren Baatar, Natashia Boland, Sebastian Bra...
RECOMB
2006
Springer
14 years 5 months ago
De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
BIBM
2009
IEEE
172views Bioinformatics» more  BIBM 2009»
13 years 10 months ago
Identifying Gene Signatures from Cancer Progression Data Using Ordinal Analysis
—A comprehensive understanding of cancer progression may shed light on genetic and molecular mechanisms of oncogenesis, and it may provide much needed information for effective d...
Yoon Soo Pyon, Jing Li
CEC
2007
IEEE
13 years 9 months ago
Evolving hypernetwork classifiers for microRNA expression profile analysis
Abstract-- High-throughput microarrays inform us on different outlooks of the molecular mechanisms underlying the function of cells and organisms. While computational analysis for ...
Sun Kim, Soo-Jin Kim, Byoung-Tak Zhang