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» Empirical codon substitution matrix
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BMCBI
2005
73views more  BMCBI 2005»
13 years 4 months ago
Empirical codon substitution matrix
Background: Codon substitution probabilities are used in many types of molecular evolution studies such as determining Ka/Ks ratios, creating ancestral DNA sequences or aligning c...
Adrian Schneider, Gina Cannarozzi, Gaston H. Gonne...
CANDC
2007
ACM
13 years 5 months ago
Codon phylogenetic distance
We develop here an analytical evolution model based on a trinucleotide mutation matrix 64 × 64 with nine substitution parameters associated with the three types of substitutions ...
Christian J. Michel
BMCBI
2010
138views more  BMCBI 2010»
13 years 5 months ago
A model-independent approach to infer hierarchical codon substitution dynamics
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
Olof Görnerup, Martin Nilsson Jacobi
ISMB
1996
13 years 6 months ago
Discovering Empirically Conserved Amino Acid Substitution Groups in Databases of Protein Families
Thispaperintroducesa methodfor identifyingempirically conservedaminoacid substitution groups.In contrast with existing approachesthat viewaminoacid substitution as a pairwisepheno...
Thomas D. Wu, Douglas L. Brutlag
CMSB
2008
Springer
13 years 6 months ago
Stochastic Analysis of Amino Acid Substitution in Protein Synthesis
Abstract. We present a formal analysis of amino acid replacement during mRNA translation. Building on an abstract stochastic model of arrival of tRNAs and their processing at the r...
Dragan Bosnacki, Huub M. M. ten Eikelder, M. N. St...