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» Statistical Analysis of Long-Range Interactions in Proteins
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BMCBI
2005
110views more  BMCBI 2005»
13 years 5 months ago
Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information
Background: The rapid publication of important research in the biomedical literature makes it increasingly difficult for researchers to keep current with significant work in their...
James W. Cooper, Aaron Kershenbaum
BMCBI
2005
169views more  BMCBI 2005»
13 years 5 months ago
Genetic interaction motif finding by expectation maximization - a novel statistical model for inferring gene modules from synthe
Background: Synthetic lethality experiments identify pairs of genes with complementary function. More direct functional associations (for example greater probability of membership...
Yan Qi 0003, Ping Ye, Joel S. Bader
BMCBI
2004
150views more  BMCBI 2004»
13 years 5 months ago
Inter-residue distances derived from fold contact propensities correlate with evolutionary substitution costs
Background: The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In p...
Gareth Williams, Patrick Doherty
RECOMB
2006
Springer
14 years 5 months ago
Integrated Protein Interaction Networks for 11 Microbes
We have combined four different types of functional genomic data to create high coverage protein interaction networks for 11 microbes. Our integration algorithm naturally handles s...
Balaji S. Srinivasan, Antal F. Novak, Jason Flanni...
RECOMB
2007
Springer
14 years 5 months ago
Protein Conformational Flexibility Analysis with Noisy Data
Abstract. Protein conformational changes play a critical role in biological functions such as ligand-protein and protein-protein interactions. Due to the noise in structural data, ...
Anshul Nigham, David Hsu