BMCBI
2006
13 years 5 months ago
2006
Background: Biochemically detailed stoichiometric matrices have now been reconstructed for various bacteria, yeast, and for the human cardiac mitochondrion based on genomic and pr...
BMCBI
2006
13 years 5 months ago
2006
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
BMCBI
2006
13 years 5 months ago
2006
Background: A new method for the prediction of protein structural classes is constructed based on Rough Sets algorithm, which is a rule-based data mining method. Amino acid compos...
BMCBI
2006
13 years 5 months ago
2006
Background: Proteomics is the study of the proteome, and is critical to the understanding of cellular processes. Two central and related tasks of proteomics are protein identifica...
BMCBI
2006
13 years 5 months ago
2006
Background: Gene expression microarray data is notoriously subject to high signal variability. Moreover, unavoidable variation in the concentration of transcripts applied to micro...
BMCBI
2006
13 years 5 months ago
2006
Background: The goal of information integration in systems biology is to combine information from a number of databases and data sets, which are obtained from both high and low th...
BMCBI
2006
13 years 5 months ago
2006
Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such...
BMCBI
2006
13 years 5 months ago
2006
Background: The development of algorithms to infer the structure of gene regulatory networks based on expression data is an important subject in bioinformatics research. Validatio...
BMCBI
2006
13 years 5 months ago
2006
Background: T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a...